Current Studies

Please see the below a list of research studies to which we are currently recruiting.  If you are interested in becoming involved in any of the studies please contact the Research Team by e-mail

SPT062 - Brains for Dementia

Brains for Dementia Research is a project of planned brain donation, with informal interview style assessments of memory, thinking, behaviour and activities of daily living at 2 to 5 year intervals for those without a diagnosis of dementia aged over 65, and every year for those with a diagnosis of dementia. Donated brain tissue and clinical data is then available to researchers working in the field of dementia.  For more information about this study please visit: 

SPT132 - Molecular Genetics of Adverse Drug Reactions

There is some evidence to suggest that side effects to some drugs may be determined by our genes (the basic building blocks of life).  It is likely that more than one gene is going to be responsible.  The purpose of this study is to identify some of these genes.  We plan to look at a number of genes (including those responsible for enzymes responsible for breakdown of drugs, and those responsible for determining immune responses).  As we do not know what genes are involved in toxic reactions to drugs, we have to test for many genes to identify the ones that may be important.  We require your permission to be able to do this. For more information please click here


The aim of the study is to provide a clinical protocol that will Predict Language Outcome and Recovery After Stroke (PLORAS). The system we are developing takes a structural brain image of a new participant with language difficulties (aphasia) and produces probabilistic estimates of long term outcome, based on whether, when, and in what respects, other participants with “matching” lesions recovered their speech and language abilities. For more information please click here

SPT177 - Adult Autism Spectrum 

Learning about the lives of adults on the autism spectrum and their relatives. This project is about engaging adults on the autism spectrum and their relatives in research. At least 1% of adults are on the autism spectrum. However, very little research has been undertaken into the life experiences of adults and older people on the autism spectrum, and how these can be improved.

To address this significant research gap, in January 2015, we began a research programme about the life experiences of adults on the autism spectrum and their relatives/carers. This project is being led by Newcastle University researchers, and funded by the research charity Autistica.  The inclusion criteria for this study is:  

  • Patients in the study who are aged over 16 years and have a diagnosis of Autism Spectrum Disorder, both with capacity and without capacity (carers can consent on behalf of those without capacity)
  • Carers of participants who have Autism Spectrum Disorder/ Asperger’s

For more information please visit The Autism Spectrum's website. You can download the promotional poster for this study by clicking on the link.

SPT179 – AD Genetics

This research aims to try and understand more about how certain genes affect the likelihood of developing Alzheimer’s disease (AD).  So far over 3000 people have helped with this research and as a result many previously unknown genes that are involved in Alzheimer’s disease have been discovered. Individuals with Early Onset Alzheimer’s Disease are now being invited to help with this research, which is the largest currently undertaken on Alzheimer's disease and will hopefully lead to new treatments and methods of diagnosis in the future. For more information please click here

SPT191 - Safetxt: a randomised controlled trial of a safer sex intervention

This study is looking to see if text messages can help people avoid sexually transmitted infections.

SPT206 - Prevalence of Pathogenic Antibodies in Psychiatric Illness (PPiP)

The study aims to understand if some cases of psychiatric illness are caused by immune system problems in some people. For more information

SPT218 - Epilepsy Register

A register for collecting and measuring outcomes of licensed Anti-Epileptic drugs in patients with Epilepsy and ID and/or pervasive developmental disorders

SPT220 - The cap-mem study

Cap Mem: exploring the cause and prevalence of memory problems in people with mental health, neurodevelopmental and neurodegenerative disorders. Anyone can take part regardless of whether they have any of these conditions or not. Click here to view the Participant Information Sheet and click here to complete the online survey which takes no more than five minutes and tick Somerset Partnership as the NHS trust at the end.

SPT239 - PrEP Impact Trial  

PrEP (HIV Pre-exposure Prophylaxis) can reduce the risk of acquiring HIV when taken as instructed. This study is being conducted to see how PrEP could be prescribed in England.

SPT260 - The IST- ID Study - Clinical & Cost Evaluation of Intensive Support Teams (IST) for adults with intellectual disabilities and challenging behaviour

The overall aim of the study is to examine characteristics of different models of IST's and investigate service user and service level outcomes.


A randomised Controlled Trial of a Structured Intervention for Expanding Social Networks in Psychosis.

SPT264 - DLB Genetics - Detecting Susceptibility for Dementia with Lewy Bodies

The objective of the study is to collect a large DLB cohort for the investigation of genetic risk factors for disease thus allowing a better understanding of the causes of DLB and providing a platform for the development of targeted treatments and preventions.

SPT265 - RADAR- Research into Antipsychotic Discontinuation and Reduction

The objective of the study is to evaluate the benefits and risks of a supported programme of antipsychotic dose reduction and discontinuation compared with continuous maintenance antipsychotic treatment in adults with multiple episode schizophrenia disorders and psychotic disorders.

SPT269 -SCIMITAR 3 year follow up – Smoking Cessation Intervention for Severe Mental Ill Health Trial.

The aim of this study is to compare a Bespoke Smoking Cessation (BSC) Service specifically tailored to individual patients with severe mental illness with “usual care” given by the patients GP or Practice without any specific adaptions or enhancements for those with mental ill health.

SPT272 - Specialist Services Evaluation

A realistic process evaluation of the implementation and impact of Forensic Child and Adolescent Mental Health Services (F-CAMHS) and SECURE STAIRS

SPT273 - Attitudes to Voices – A survey exploring the factors associated with clinicians perspectives on hearing voices.

A limited literature suggests that clinicians can find it difficult to talk to patients about their voice hearing experiences.  These difficulties may reduce the likelihood of patients gaining access to evidence based treatments.  This study aims to explore clinicians’ views, attitudes and experiences with regards to working with patients who hear distressing voices.

SPT279 - The Role of Different Diets in Children who are Gastrostomy Fed

What are the risks, benefits and resource implications for using home-blended food for children with gastrostomy tubes compared to currently recommended formula feeds?

SPT282 - High Energy High Protein Peptide Feed Study (Nutricia)

The aim of this study is to evaluate the gastro-intestinal tolerance, compliance and acceptability of a ready to use, liquid, high energy density (1.5kcal/ml), high protein (7.5g/100ml), peptide-based feed (Nutrison Peptisorb Energy HP) for use in adults who are unable to tolerate whole protein feeds, or who would benefit from a peptide-based feed.

SPT283 - Compassion care: definition, barriers and aids. A mixed-methods study in adolescent inpatient settings.

This project is all about compassionate care in inpatient adolescent psychiatric wards.

SPT288 - Exploring Unusual Feelings 

This study is a questionnaire study where patients with non-affective psychosis will answer a pack of 10 questionnaires (approx. 30 minutes) once. We will then use the latest statistical methods (network analyses) to understand what factors might cause dissociation, and whether dissociation might cause psychotic symptoms.

SPT290 - EMPHeP Project - Efficiency, cost and quality of mental healthcare provision

The purpose of this study is to examine what organisational factors drive improvements in cost and quality of care in Mental Health Trusts.